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What is OPSUMIT®?

OPSUMIT® is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1). PAH is high blood pressure in the arteries of your lungs. OPSUMIT® can:

The most important information about OPSUMIT® (macitentan)

Do not take OPSUMIT® if you are pregnant or trying to get pregnant. OPSUMIT® can cause serious birth defects if taken while pregnant.

Women who are able to get pregnant must have negative pregnancy tests:


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Once-Daily Dose of OPSUMIT®:

  • It is a once daily pill that can be taken with or without food
  • It can be taken alone or in combination with PDE-5 inhibitors or inhaled prostanoids, which are types of PAH medicines
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Instructions for taking OPSUMIT®:

  • Take OPSUMIT® exactly as your doctor recommends
  • Do not stop taking OPSUMIT® unless you're advised to do so by your doctor
  • You can take OPSUMIT® with or without food
  • If you miss a dose of OPSUMIT®, take it as soon as you remember that same day. You can take the next dose of OPSUMIT® at your regular time. Do not take 2 doses at the same time to make up for a missed dose

What you may expect from OPSUMIT® treatment

It may take some time to feel the benefits of treatment. One of the first changes you may notice is the ability to do more physical activity with fewer symptoms. If your symptoms do not get worse over time, it may mean that your PAH treatments are working. Talk to your healthcare team about any changes in your symptoms.

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Tell your doctor about any of the following:

  • If you take too much OPSUMIT®
  • You have side effects that bother you or do not go away
  • Any new medicines you start taking
  • Your medical conditions, as well as all the medicines, vitamins, and supplements you take. OPSUMIT® and other medicines may affect each other causing side effects. Tell your doctor right away if you take an HIV medicine