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What is OPSUMIT®?

OPSUMIT® is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1). PAH is high blood pressure in the arteries of your lungs. OPSUMIT® can:

The most important information about OPSUMIT® (macitentan)

Do not take OPSUMIT® if you are pregnant or trying to get pregnant. OPSUMIT® can cause serious birth defects if taken while pregnant.

Women who are able to get pregnant must have negative pregnancy tests:

Treating PAH

PAH treatments target 3 pathways

Blood vessels in your lungs may be affected when there is either too much or too little of certain naturally occurring substances in your body: endothelin, nitric oxide, and/or prostacyclin. There are PAH treatments available that target each of these pathways:

Endothelin pathway

Endothelin receptor antagonists (ERAs), such as OPSUMIT®, work here. Learn about the benefits of OPSUMIT®.

Nitric oxide pathway

Phosphodiesterase type-5 inhibitors (PDE-5 inhibitors) and soluble guanylate cyclase stimulators (sGCs) work here.

Prostacyclin pathway

Prostacyclin, prostacyclin analogs, and prostacyclin receptor agonists work here.