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What is OPSUMIT®?

OPSUMIT® is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1). PAH is high blood pressure in the arteries of your lungs. OPSUMIT® can:

The most important information about OPSUMIT® (macitentan)

Do not take OPSUMIT® if you are pregnant or trying to get pregnant. OPSUMIT® can cause serious birth defects if taken while pregnant.

Women who are able to get pregnant must have negative pregnancy tests:

Personalized support for you

Everyone faces PAH differently. Once you and your doctor have decided that a Janssen PAH medication is right for you, you can join PAH‍ Companion withMe—a suite of patient support resources personalized just for you. You'll receive one-on-one educational support to help with your prescribed Janssen PAH medication, plus customized tools and resources to help you take a more active role in your care.

When you participate in PAH Companion withMe, you'll have access to:

My PAH Companion

One-on-one conversations with a trained, dedicated PAH Companion—‍someone who specializes in helping people living with PAH. Your PAH Companion will communicate with you via phone, email, or text.

My Resources

Educational resources to help with your prescribed Janssen PAH medication, tailored to your specific needs, questions, and interests.


My Tips

Ongoing support and education on living with PAH to help you partner with your healthcare team and engage with your support network.

My Community

Connection to peer support groups, current PAH information and resources, and digital tools to help you track and monitor your health.

Contact a PAH Companion

If you're receiving a Janssen PAH medication, you can learn more about PAH Companion withMe by calling 866-300-1818, Monday-Friday, 8 AM-9 PM ET.

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PAH Companion withMe is limited to education about your Janssen PAH therapy, its administration, and/or PAH. It is not intended to provide medical advice, replace a treatment plan you receive from your healthcare team or serve as a reason for you to start or stay on treatment.